Contractility of Diabetic Human Corpus Cavernosum Smooth Muscle in Response to Serotonin Mediated via Rho-Kinase

被引：7

作者：

Murat, Nergis ^{[3
]}

Soner, Burak Cem ^{[1
]}

Demir, Omer ^{[2
]}

Esen, Adil ^{[2
]}

Gidener, Sedef ^{[1
]}

机构：

[1] Dokuz Eylul Univ, Dept Pharmacol, Fac Med, TR-35340 Izmir, Turkey

[2] Dokuz Eylul Univ, Dept Urol, Fac Med, TR-35340 Izmir, Turkey

[3] Dokuz Eylul Univ, Adv Profess Sch Hlth Sci, TR-35340 Izmir, Turkey

来源：

PHARMACOLOGY | 2009年 / 84卷 / 01期

关键词：

Diabetes mellitus; Corpus cavernosum; human; Rho-kinase; Serotonin; ERECTILE; 5-HYDROXYTRYPTAMINE; DYSFUNCTION; MELLITUS;

D O I：

10.1159/000221380

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background/Aims: Serotonin (5-hydroxytryptamine, 5-HT)-induced contraction and the involvement of RhoA/Rho-kinase pathway in the 5-HT-induced contraction was investigated isometrically in vitro in both diabetic and nondiabetic human corpus cavernosum (HCC) tissues. Methods: HCC tissues were obtained from 12 patients. The response to 5-HT (10(-9) to 10(-5) mol/l) was studied in isolated HCC tissues in the absence and in the presence of a Rho-kinase inhibitor (Y-27632). Results: Preincubation with Y-27632 attenuated maximum contractions induced by 5-HT in tissues of both nondiabetics and diabetics. When diabetic and nondiabetic groups were compared, no significant difference was seen in 5-HT-induced contraction alone, but in the presence of Y-27632, 5-HT-induced contraction was significantly higher in the diabetic group. Conclusion: These results suggest that the Rho-kinase-mediated pathway plays an important role for 5-HT-induced contraction in diabetic corpus cavernosum tissues. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：24 / 28

页数：5

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