Palladium-phosphinous acid-catalyzed Sonogashira cross-coupling reactions in water

被引：96
作者：
Wolf, C [1 ]
Lerebours, R [1 ]
机构：
[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2004年 / 2卷 / 15期
关键词：
D O I：
10.1039/b407773c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-phosphinous acid-catalyzed Sonogashira cross-coupling reaction that proceeds in water under air atmosphere in the absence of organic co-solvents has been developed. Disubstituted alkynes have been prepared in up to 91% yield by POPd-catalyzed coupling of various aryl halides including chlorides in the presence of tetrabutylammonium bromide and pyrrolidine or NaOH.
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页码：2161 / 2164
页数：4
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