Recent advances on cellular therapies and immune modulators for graft-versus-host disease

被引：7

作者：

Filippini, Perla ^{[1
]}

Rutella, Sergio ^{[2
]}

机构：

[1] IRCCS San Raffaele Pisana, Dept Syst Med, Doha, Qatar

[2] Qatar Fdn, Sidra Med & Res Ctr, Div Translat Med, Res Branch, Doha, Qatar

来源：

EXPERT REVIEW OF CLINICAL IMMUNOLOGY | 2014年 / 10卷 / 10期

关键词：

bone marrow microenvironment; cytokines; dendritic cells; hematopoietic stem cell transplantation; immunotherapy; Treg; COLONY-STIMULATING FACTOR; REGULATORY T-CELLS; MESENCHYMAL STROMAL CELLS; TOLEROGENIC DENDRITIC CELLS; UMBILICAL-CORD BLOOD; BONE-MARROW; G-CSF; INDOLEAMINE 2,3-DIOXYGENASE; ACUTE GVHD; EX-VIVO;

D O I：

10.1586/1744666X.2014.955475

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The efficacy of allogeneic hematopoietic stem cell transplantation is counterbalanced by the occurrence of life-threatening immune-mediated complications, such as graft-versus-host disease (GVHD), a multistep disease which is reportedly fatal to approximately 15% of transplant recipients. It is now established that T-cell-dendritic cell interactions, T-cell activation, release of proinflammatory cytokines and T-cell trafficking partake in GVHD pathogenesis. This article will focus on the most recent strategies aimed at preventing/treating GVHD by manipulating components of the innate and adaptive immune response from both the donor and the host.

引用

页码：1357 / 1374

页数：18

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