Hedgehog Signaling Regulates the Survival of Gastric Cancer Cells by Regulating the Expression of Bcl-2

被引：38
作者：
Han, Myoung-Eun [1 ,2 ]
Lee, Young-Suk [1 ]
Baek, Sun-Yong [1 ]
Kim, Bong-Seon [1 ]
Kim, Jae-Bong [1 ]
Oh, Sae-Ock [1 ,2 ]
机构：
[1] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan 626770, South Korea
[2] Pusan Natl Univ, Med Res Ctr Ischem Tissue Regenerat, Yangsan 626770, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 07期
关键词：
gastric cancer; hedgehog signaling; apoptosis; Bcl-2; SONIC HEDGEHOG; DEATH; PATHWAY; FAMILY; GROWTH; SKIN; DIFFERENTIATION; MEDULLOBLASTOMA; CARCINOGENESIS; CYCLOPAMINE;
D O I：
10.3390/ijms10073033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastric cancer is the second most common cause of cancer deaths worldwide. The underlying molecular mechanisms of its carcinogenesis are relatively poorly characterized. Hedgehog (Hh) signaling, which is critical for development of various organs including the gastrointestinal tract, has been associated with gastric cancer. The present study was undertaken to reveal the underlying mechanism by which Hh signaling controls gastric cancer cell proliferation. Treatment of gastric cancer cells with cyclopamine, a specific inhibitor of Hh signaling pathway, reduced proliferation and induced apoptosis of gastric cancer cells. Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9. Moreover, Bcl-2 expression was significantly reduced by cyclopamine treatment. These results suggest that Hh signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.
引用
收藏
页码：3033 / 3043
页数：11
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