Leptin inhibits bone formation not only in rodents, but also in sheep

被引：61

作者：

Pogoda, Pia

Egermann, Marcus

Schnell, Johann C.

Priemel, Matthias

Schilling, Arndt F.

Alini, Mauro

Schinke, Thorsten

Rueger, Johannes M.

Schneider, Erich

Clarke, Lain

Amling, Michael

机构：

[1] Univ Hamburg, Med Ctr, Ctr Biomech Expt Trauma Surg & Skeletal Biol, Dept Trauma Hand & Reconstruct Surg, D-20246 Hamburg, Germany

[2] AO Res Inst, Davos, Switzerland

[3] Monash Univ, Dept Physiol, Melbourne, Vic 3004, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

leptin; bone formation; osteoporosis; histomorphometry; ewe;

D O I：

10.1359/JBMR.060709

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study examines the effect of long-term ICV administration of leptin in ewes. We found that central application significantly decreased osteoblast activity as measured by serum analysis as well as by histomorphometry, resulting in decreased trabecular bone volume. These data provide additional evidence that bone formation and therefore bone remodeling is at least in part centrally controlled.

引用

页码：1591 / 1599

页数：9

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