Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas

被引：28
作者：
Calatozzolo, Chlara
Maderna, Ernanuela
Pollo, Bianco
Gelati, Maurizio
Marras, Carlo
Silvani, Antonio
Croci, Danilo
Boiardi, Arnerigo
Salmaggi, Andrea
机构：
[1] Ist Nazl Neurol Carlo Besta, Div Neurol 2, Dept Neurol, I-20133 Milan, Italy
[2] Ist Nazl Neurol Carlo Besta, Dept Neuropathol, I-20133 Milan, Italy
[3] Ist Nazl Neurol Carlo Besta, Dept Lab Clin Invest, I-20133 Milan, Italy
[4] Ist Nazl Neurol Carlo Besta, Dept Neurosurg, I-20133 Milan, Italy
来源：
CANCER BIOLOGY & THERAPY | 2006年 / 5卷 / 07期
关键词：
CXCL12; TTP; PDGFR-beta; PDGF-B; nestin; MVD; oligoastrocytoma; oligodendroglioma;
D O I：
10.4161/cbt.5.7.2838
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Both clinical and biological features have been reported as prognostic factors in low-grade gliomas. Among these, histotype, tumor size, enhancement, age and genetic pattern. Microvessel density (MVD) has been correlated to clinical outcome in astrocytomas, but its impact in oligodendrogliomas and mixed tumors is not sure. The pro-angiogenic chemokine stromal cell-derived factor (SDF-1 /CXCL12) and its receptor CXC chemokine receptor 4 (CXCR4) have been described in low-grade gliomas, with a correlation between CXCL12 expression and shorter time to progression (TTP). The intermediate filament Nestin is expressed in proliferating vessels. Platelet-derived growth factor B (PDGF-B) and its receptor PDGFR-P are also involved in angiogenesis and malignant progression in gliomas.
引用
收藏
页码：827 / 832
页数：6
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