Nanobiotechnology and its applications in drug delivery system: a review

被引:63
作者
Khan, Imran [1 ,2 ]
Khan, Momin [1 ]
Umar, Muhammad Naveed [3 ]
Oh, Deog-Hwan [2 ]
机构
[1] Quaid I Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan
[2] Kangwon Natl Univ, Sch Bioconvergence Sci & Technol, Dept Food Sci & Biotechnol, Chunchon 200701, Gangwon, South Korea
[3] Univ Malakand, Dept Chem, Chakdara 23800, Pakistan
关键词
nanomedicine; drug delivery systems; reviews; nanoparticles; cellular biophysics; polymers; biomedical materials; nanobiotechnology; drug delivery system; review; nanobiopharmaceuticals; nanosystems; biological properties; therapeutic efficacy; cell; polymeric nanoparticles; IN-VITRO EVALUATION; CANCER-THERAPY; QUANTUM DOTS; PLGA NANOPARTICLES; ANTICANCER DRUGS; BLOCK-COPOLYMERS; MICELLES; LIPOSOMES; NANOTECHNOLOGY; POLYMERSOMES;
D O I
10.1049/iet-nbt.2014.0062
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Nanobiotechnology holds great potential in various regimes of life sciences. In this review, the potential applications of nanobiotechnology in various sectors of nanotechnologies, including nanomedicine and nanobiopharmaceuticals, are highlighted. To overcome the problems associated with drug delivery, nanotechnology has gained increasing interest in recent years. Nanosystems with different biological properties and compositions have been extensively investigated for drug delivery applications. Nanoparticles fabricated through various techniques have elevated therapeutic efficacy, provided stability to the drugs and proved capable of targeting the cells and controlled release inside the cell. Polymeric nanoparticles have shown increased development and usage in drug delivery as well as in diagnostics in recent decades.
引用
收藏
页码:396 / 400
页数:5
相关论文
共 69 条
[1]   PHARMACOKINETICS OF STEALTH VERSUS CONVENTIONAL LIPOSOMES - EFFECT OF DOSE [J].
ALLEN, TM ;
HANSEN, C .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1068 (02) :133-141
[2]   Drug delivery systems: Entering the mainstream [J].
Allen, TM ;
Cullis, PR .
SCIENCE, 2004, 303 (5665) :1818-1822
[3]   LARGE UNILAMELLAR LIPOSOMES WITH LOW UPTAKE INTO THE RETICULOENDOTHELIAL SYSTEM [J].
ALLEN, TM ;
CHONN, A .
FEBS LETTERS, 1987, 223 (01) :42-46
[4]  
Arap Wadih, 1998, Current Opinion in Oncology, V10, P560, DOI 10.1097/00001622-199811000-00014
[5]   Molecular weight dependence of polymersome membrane structure, elasticity, and stability [J].
Bermudez, H ;
Brannan, AK ;
Hammer, DA ;
Bates, FS ;
Discher, DE .
MACROMOLECULES, 2002, 35 (21) :8203-8208
[6]   Nanoparticles in cancer therapy and diagnosis [J].
Brigger, I ;
Dubernet, C ;
Couvreur, P .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651
[7]   Nanomaterials and nanoparticles: Sources and toxicity [J].
Buzea, Cristina ;
Pacheco, Ivan I. ;
Robbie, Kevin .
BIOINTERPHASES, 2007, 2 (04) :MR17-MR71
[8]   Micelles of different morphologies - Advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery [J].
Cai, Shenshen ;
Vijayan, Kandaswamy ;
Cheng, Debbie ;
Lima, Eliana M. ;
Discher, Dennis E. .
PHARMACEUTICAL RESEARCH, 2007, 24 (11) :2099-2109
[9]   Functional and site-specific macromolecular micelles as high potential drug carriers [J].
Cammas-Marion, S ;
Okano, T ;
Kataoka, K .
COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) :207-215
[10]   Luminescent quantum dots for multiplexed biological detection and imaging [J].
Chan, WCW ;
Maxwell, DJ ;
Gao, XH ;
Bailey, RE ;
Han, MY ;
Nie, SM .
CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :40-46