Paraneoplastic thrombocytosis: the secrets of tumor self-promotion

被引：147

作者：

Lin, Richard J. ^{[1
]}

Afshar-Kharghan, Vahid ^{[2
]}

Schafer, Andrew I. ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA

[2] Univ Texas MD Anderson Canc Ctr, Div Internal Med, Houston, TX 77030 USA

来源：

BLOOD | 2014年 / 124卷 / 02期

基金：

美国国家卫生研究院;

关键词：

OVARIAN-CANCER; LUNG-CANCER; P-SELECTIN; PREOPERATIVE THROMBOCYTOSIS; PRETREATMENT THROMBOCYTOSIS; PROGNOSTIC-SIGNIFICANCE; PLATELETS; METASTASIS; CELLS; INTERLEUKIN-6;

D O I：

10.1182/blood-2014-03-562538

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feedback loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. Specific molecular pathways have been identified in which tumors can stimulate platelet production and activation; activated platelets can, in turn, promote tumor growth and metastasis. Taken together, these findings provide exciting new potential targets for therapeutic intervention.

引用

页码：184 / 187

页数：4

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