Recent advances in scleroderma-associated pulmonary hypertension

被引:8
作者
Highland, Kristin B. [1 ]
机构
[1] Cleveland Clin Fdn, Resp Inst, Cleveland, OH 44195 USA
关键词
pulmonary arterial hypertension; pulmonary hypertension; scleroderma; systemic sclerosis; RIGHT-VENTRICULAR DYSFUNCTION; BRAIN NATRIURETIC PEPTIDE; BASE-LINE CHARACTERISTICS; ARTERIAL-HYPERTENSION; SYSTEMIC-SCLEROSIS; IRON-DEFICIENCY; AMERICAN-COLLEGE; EXPERT CONSENSUS; CONTROLLED-TRIAL; DIGITAL ULCERS;
D O I
10.1097/BOR.0000000000000114
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review This review summarizes recent advances in pulmonary hypertension, a leading cause of morbidity and mortality in scleroderma (SSc). Recent findings Although WHO Group I pulmonary arterial hypertension (PAH) is the most common cause of pulmonary hypertension, all WHO Groups can occur. PAH is now a criterion for the diagnosis of SSc. Results of recent research have resulted in greater insight into the epidemiology of SSc-pulmonary hypertension with regard to prevalence, incidence and clinical risk factors. There is also greater understanding of the role of inflammation in the pathogenesis of SSc-PAH. Advances have also been made in the evaluation and screening of patients with SSc-PAH, and early detection has been shown to improve survival in a disease that typically has worse outcomes than other forms of PAH. Finally, recommendations have been made with regard to goal-directed therapy. Summary Although there have been many recent advances in SSc-pulmonary hypertension, further research is needed in order to prevent/cure this deadly complication.
引用
收藏
页码:637 / 645
页数:9
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