Every amino acid matters: essential contributions of histone variants to mammalian development and disease

被引：250

作者：

Maze, Ian ^{[1
]}

Noh, Kyung-Min ^{[1
]}

Soshnev, Alexey A. ^{[1
]}

Allis, C. David ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromatin Biol & Epigenet, New York, NY 10065 USA

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 04期

关键词：

CENTROMERE PROTEIN-A; NUCLEOSOME-FREE REGIONS; INACTIVE X-CHROMOSOME; LINKER HISTONE; H3; VARIANTS; PERICENTRIC HETEROCHROMATIN; GENOMIC INSTABILITY; IONIZING-RADIATION; DRIVER MUTATIONS; H1; VARIANT;

D O I：

10.1038/nrg3673

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Despite a conserved role for histones as general DNA packaging agents, it is now clear that another key function of these proteins is to confer variations in chromatin structure to ensure dynamic patterns of transcriptional regulation in eukaryotes. The incorporation of histone variants is particularly important to this process. Recent knockdown and knockout studies in various cellular systems, as well as direct mutational evidence from human cancers, now suggest a crucial role for histone variant regulation in processes as diverse as differentiation and proliferation, meiosis and nuclear reprogramming. In this Review, we provide an overview of histone variants in the context of their unique functions during mammalian germ cell and embryonic development, and examine the consequences of aberrant histone variant regulation in human disease.

引用

页码：259 / 271

页数：13

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