MITOCHONDRIA: Are mitochondria accessory to metastasis?

被引：36

作者：

Amoedo, Nivea Dias ^{[1
]}

Rodrigues, Mariana Figueiredo ^{[1
]}

Rumjanek, Franklin David ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo De Meis, BR-21941590 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2014年 / 51卷

关键词：

Metastasis; Anoikis resistance; Mitochondrial respiration; Oxidative metabolism; Tumor microenvironment; EPITHELIAL CANCER-CELLS; TUMOR-CELLS; ENERGY-METABOLISM; BIOGENESIS; MUTATIONS; CAPACITY;

D O I：

10.1016/j.biocel.2014.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the nineteenth century the importance of mitochondria in cellular physiology has been growing steadily. Not only the organelle harbors the main systems for ATP generation, but also buffers the redox potential in the cytosol and is one of the protagonists of the intrinsic pathway for apoptosis. In tumor cells, mitochondria went from being dysfunctional compartments to playing a supportive or perhaps even a triggering part in metastasis. This "Organelle In Focus" article discusses the classical metabolic events that occur in mitochondria and why these pathways could be essential for the onset of the malignant phenotype. Finally, we propose that the oxidative metabolism of tumor cells in conjunction with the inactivation of anoikis may have been coopted through a non-adaptive evolutionary process. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：53 / 57

页数：5

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