The role of mechanosensitive Piezo1 channel in diseases

被引：20

作者：

Song, Siqi ^{[1
]}

Zhang, Hong ^{[2
]}

Wang, Xiaoya ^{[1
]}

Chen, Wei ^{[3
]}

Cao, Wenxuan ^{[1
]}

Zhang, Zhe ^{[4
]}

Shi, Chunying ^{[1
]}

机构：

[1] Qingdao Univ, Dept Human Anat Histol & Embryol, Sch Basic Med, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Univ, Affiliated Hosp, Dept Cardiac Surg, Qingdao 266071, Shandong, Peoples R China

[3] Third Mil Med Univ, Affiliated Xinqiao Hosp, Dept Urol, Chongqing 400038, Peoples R China

[4] Qingdao Univ, Sch Basic Med, Coll Med, Qingdao 266071, Shandong, Peoples R China

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2022年 / 172卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Ion channel; Genetic diseases; Mechanical force; Piezo1; Potential treatments; ION CHANNELS; HEREDITARY XEROCYTOSIS; CA2+ RESPONSE; MUTATIONS; STRETCH; PROTEIN; TRPV4; TRANSDUCTION; ACTIVATION; PRESSURE;

D O I：

10.1016/j.pbiomolbio.2022.04.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation, cellular migration, proliferation, and apoptosis but is also important for human diseases of various systems. The complete loss of Piezo1 and Piezo2 function is fatal in the embryonic period. This review summarizes the role of Piezo1 in diseases of different systems and perspectives potential treatments related to Piezo1 for these diseases. (c) 2022 Elsevier Ltd. All rights reserved.

引用

页码：39 / 49

页数：11

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