Negative Association of Serum IL-6 and IL-17 with Type-II Diabetes Retinopathy

被引：1

作者：

Afzal, Nadeem ^{[1
]}

Zaman, Shakeela ^{[2
]}

Asghar, Aneela ^{[3
]}

Javed, Khursheed ^{[1
]}

Shahzad, Faheem ^{[1
]}

Zafar, Abu ^{[4
]}

Nagi, Abdul Hanan ^{[5
]}

机构：

[1] Univ Hlth Sci, Dept Immunol, Lahore, Pakistan

[2] Children Hosp & Inst Child Hlth, Lahore, Pakistan

[3] Sahiwal Med Coll, Dept Biochem, Sahiwal, Pakistan

[4] Amin Hayat Mem Diabet Ctr, Lahore, Pakistan

[5] Univ Hlth Sci, Dept Pathol, Lahore, Pakistan

来源：

IRANIAN JOURNAL OF IMMUNOLOGY | 2014年 / 11卷 / 01期

关键词：

Cytokine; Diabetes Mellitus; Inflammation; Retinopathy; NECROSIS-FACTOR-ALPHA; INTERLEUKIN-6; CELLS; PREVALENCE; EPIDEMIOLOGY; INFLAMMATION; MELLITUS; ONSET;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Diabetes mellitus (DM) is a health concern which leads to complications such as retinopathy. Pakistan has 6.9 million people living with DM and this toll will be doubled by 2025. Objective: To determine serum IL-6 and IL-17 of type 2 diabetes mellitus (T2DM) patients with retinopathy. Methods: In this cross-sectional case-control study, 212 subjects enrolled which were categorized into 3 groups. Group-I included 30 subjects without diabetes, group-II consisted of 30 subjects with T2DM without retinopathy and group-III consisted of 152 subjects with T2DM and retinopathy. Serum IL-6 and IL-17 levels were determined by ELISA. Data was analysed using SPSS 17.0 and one way ANOVA to observe group mean differences. Results: Longer mean duration of disease was detected in group-III than group-II (p=0.007). Highest IL-6 level was detected in group-II and highest IL-17 level was detected in group-I. For IL-6, significant differences were detected among groups in total, between Group-I and Group-III and between Group-II and Group-III (p<0.0001 each). Regarding IL-17, significant differences were found among groups in total (p=0.002) and between Group-I and Group-III (p=0.001). No significant difference in the percentages of HbA1c observed between groups. Conclusions: Age, gender and duration of diabetes contribute to T2DM retinopathy. Serum IL-6 and IL-17 were inversely associated with T2DM retinopathy.

引用

页码：40 / 48

页数：9

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