Impulsivity trait in the early symptomatic BACHD transgenic rat model of Huntington disease

被引：20

作者：

Manfre, Giuseppe ^{[1
,2
]}

Doyere, Valerie ^{[3
,4
]}

Bossi, Simon ^{[3
,4
]}

Riess, Olaf ^{[1
]}

Huu Phuc Nguyen ^{[1
]}

El Massioui, Nicole ^{[3
,4
]}

机构：

[1] Univ Tubingen, Inst Med Genet & Appl Genom, Tubingen, Germany

[2] Univ Tubingen, IMPRS Cognit & Syst Neurosci, Tubingen, Germany

[3] Univ Paris 11, UMR 9197, Paris Saclay Inst Neurosci Neuro PSI, F-91405 Orsay, France

[4] CNRS, F-91405 Orsay, France

来源：

BEHAVIOURAL BRAIN RESEARCH | 2016年 / 299卷

关键词：

Huntington disease; Impulsivity; Executive functions; Decision making; Transgenic rats; EXECUTIVE FUNCTIONS; PREFRONTAL CORTEX; INHIBITION; CLASSIFICATION; EXPRESSION; AMYGDALA;

D O I：

10.1016/j.bbr.2015.11.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Impulsivity trait was characterized in 3-5 months old BACHD rats, a transgenic model of Huntington disease, using (1) the delay discounting task to assess cognitive/choice impulsivity, and (2) the Differential Reinforcement of Low Rate of Responding task to evaluate motor/action impulsivity. Transgenic animals showed a high level of choice impulsivity and, to a lesser extent, action impulsivity. Our results provide the first evidence that the transgenic BACHD rat (TG5 line) displays impulsivity disorder as early as 3 months old, as described in early symptomatic HD patients, thus adding to the face validity of the rat model. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：6 / 10

页数：5

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