A pH-sensitive near-infrared fluorescent probe with alkaline pKa for chronic wound monitoring in diabetic mice

被引：40

作者：

Mai, Hengtang ^{[1
]}

Wang, Yu ^{[2
]}

Li, Shuang ^{[1
]}

Jia, Ruizhen ^{[1
]}

Li, Sixian ^{[1
]}

Peng, Qian ^{[1
]}

Xie, Yan ^{[1
]}

Hu, Xiang ^{[2
]}

Wu, Song ^{[1
]}

机构：

[1] Wuhan Univ, Sch Pharmaceut Sci, Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Wuhan 430072, Hubei, Peoples R China

[2] Wuhan Univ, Dept Orthopaed Trauma & Microsur, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 51期

基金：

中国国家自然科学基金;

关键词：

INTRACELLULAR PH; SKIN SURFACE;

D O I：

10.1039/c9cc02289a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pH-sensitive near-infrared fluorescent probe with alkaline pK(a), AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wounds in diabetic mice.

引用

页码：7374 / 7377

页数：4

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