Mobile DNA elements in the generation of diversity and complexity in the brain

被引：186

作者：

Erwin, Jennifer A. ^{[1
]}

Marchetto, Maria C. ^{[1
]}

Gage, Fred H. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 08期

关键词：

INDEPENDENT LINE-1 RETROTRANSPOSITION; CPG-BINDING PROTEIN-2; L1; RETROTRANSPOSITION; RETT-SYNDROME; TRANSPOSABLE ELEMENTS; NERVOUS-SYSTEM; CULTURED-CELLS; HUMAN GENOMES; STEM-CELLS; NEURONS;

D O I：

10.1038/nrn3730

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.

引用

页码：497 / 506

页数：10

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