CNS activity of Calotropis gigantea roots

被引:59
作者
Argal, Ameeta [1 ]
Pathak, Anupam. Kumar [1 ]
机构
[1] Barkatullah Univ, Dept Pharm, Bhopal 462026, MP, India
关键词
Calotropis gigantea; anticonvulsant; analgesic; anxiolytic; alcoholic extract; peeled roots;
D O I
10.1016/j.jep.2005.12.024
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Alcoholic extract of peeled roots of Calotropis gigantea R.Br. (Asclepiadaceae) was tested orally in albino rats at the dose level of 250 and 500 mg/kg bodyweight for CNS activity. Prominent analgesic activity was observed in Eddy's hot plate method and acetic acid induced writhings. The paw licking time was delayed and the numbers of writhings were greatly reduced. Significant anticonvulsant activity was seen as there was a delay in the onset of pentylenetetrazole induced convulsions as well as decrease in its severity. The extract treated rats spent more time in the open arm of EPM showing its antianxiety activity. There was a decrease in the locomotor activity. The fall off time (motor coordination) was also decreased. A potentiation in the pentobarbitone-induced sleep due to the sedative effect of the extract was observed. No mortality was seen upto the dose of 1 g/kg. These results show the analgesic, anticonvulsant, anxiolytic and sedative effect of the extract. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:142 / 145
页数:4
相关论文
共 23 条
[11]  
KIRTIKAR KR, 1995, SUDHINDHRA NATH BASU, V3, P1609
[12]  
Kulkarni SK, 1999, HDB EXPT PHARM, P133
[13]  
Leewanich P, 1996, BIOL PHARM BULL, V19, P394, DOI 10.1248/bpb.19.394
[14]  
MANANDHAR MP, 1990, ETHNOBOTANY, V2, P33
[15]   ISOLATION, CRYSTALLIZATION, AND PROPERTIES OF CALOTROPIN-DI AND CALOTROPIN-DII FROM CALOTROPIS-GIGANTEA [J].
PAL, G ;
SINHA, NK .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1980, 202 (02) :321-329
[16]   FLAVONOL GLYCOSIDES FROM CALOTROPIS-GIGANTEA [J].
SEN, S ;
SAHU, NP ;
MAHATO, SB .
PHYTOCHEMISTRY, 1992, 31 (08) :2919-2921
[17]  
Sharma V., 2001, DRAVYAGUNA VIGYAN, V2, P435
[18]   CHEMICAL INVESTIGATION OF ASCLEPIAS-CURASSAVICA .2. STRUCTURE OF ASCLEPIN AND SOME OBSERVATIONS ON NMR-SPECTRA OF CALOTROPIS-GLYCOSIDES [J].
SINGH, B ;
RASTOGI, RP .
PHYTOCHEMISTRY, 1972, 11 (02) :757-+
[19]  
Sonavane Ganeshcandra, 2001, Indian Journal of Pharmacology, V33, P417
[20]  
TSUJI M, 2000, NIPPON YAKURIGAKU ZA, V15, P29