Implementing Fixed Dose Combination Medications for the Prevention and Control of Cardiovascular Diseases

被引：20

作者：

Webster, Ruth ^{[1
,2
]}

Murphy, Adrianna ^{[3
]}

Bygrave, Helen ^{[4
]}

Ansbro, Eimhin ^{[3
]}

Grobbee, Diederick E. ^{[5
]}

Perel, Pablo ^{[3
,6
]}

机构：

[1] Univ Technol Sydney, Ctr Hlth Econ Res & Evaluat, Sydney, NSW, Australia

[2] Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia

[3] London Sch Hyg & Trop Med, Ctr Global Chron Dis, London, England

[4] Med Sans Frontieres Access Campaign, Geneva, Switzerland

[5] UMC Utrecht, Utrecht, Netherlands

[6] World Heart Federat, Geneva, Switzerland

来源：

GLOBAL HEART | 2020年 / 15卷 / 01期

关键词：

Cardiovascular Prevention; Polypills; Hypertension; Public Health; Combination therapy; LOW-INCOME COUNTRIES; QUALITY-OF-LIFE; SECONDARY PREVENTION; MIDDLE-INCOME; HIGH-RISK; DOUBLE-BLIND; USUAL CARE; POLYPILL; ADHERENCE; STRATEGY;

D O I：

10.5334/gh.860

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Achieving the WHO 25 by 25 targets of at least 50% of eligible people receiving drug therapy and counselling to prevent heart attack and stroke and achieving 80% availability of essential medicines requires novel approaches. Use of single medicines from various drug classes, rather than combinations of such medicines, to address the risk associated with established CVD thus far has failed to provide a scalable, global solution to address the growing epidemic of CVD. FDC therapy in patients at high risk of CVD events has been shown to be effective in improving adherence and coverage of essential preventive medications and could be a core component to achieve WHO goals if part of global CVD prevention and control strategy.

引用

页数：6

共 33 条

[1]

Airoldi M, 2010, PATIENT PREFER ADHER, V4, P115

[2]

[Anonymous], 2010, TREATM TUB GUID

[3]

[Anonymous], 2017, Tackling NCDs: best buys and other recommended interventions for the prevention and control of noncommunicable deseases

[4]

Castellano JM, 2014, J AM COLL CARDIOLOGY

[5] The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings [J].

Gilks, Charles F. ;

Crowley, Siobhan ;

Ekpini, Rene ;

Gove, Sandy ;

Perriens, Jos ;

Souteyrand, Yves ;

Sutherland, Don ;

Vitoria, Marco ;

Guerma, Teguest ;

De Cock, Kevin .

LANCET, 2006, 368 (9534) :505-510

[6] Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents A Meta-Analysis [J].

Gupta, Ajay K. ;

Arshad, Shazia ;

Poulter, Neil R. .

HYPERTENSION, 2010, 55 (02) :399-407

[7] Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data [J].

Khatib, Rasha ;

Mckee, Martin ;

Shannon, Harry ;

Chow, Clara ;

Rangarajan, Sumathy ;

Teo, Koon ;

Wei, Li ;

Mony, Prem ;

Mohan, Viswanathan ;

Gupta, Rajeev ;

Kumar, Rajesh ;

Vijayakumar, Krishnapillai ;

Lear, Scott A. ;

Diaz, Rafael ;

Avezum, Alvaro ;

Lopez-Jaramillo, Patricio ;

Lanas, Fernando ;

Yusoff, Khalid ;

Ismail, Noorhassim ;

Kazmi, Khawar ;

Rahman, Omar ;

Rosengren, Annika ;

Monsef, Nahed ;

Kelishadi, Roya ;

Kruger, Annamarie ;

Puoane, Thandi ;

Szuba, Andrzej ;

Chifamba, Jephat ;

Temizhan, Ahmet ;

Dagenais, Gilles ;

Gafni, Amiram ;

Yusuf, Salim .

LANCET, 2016, 387 (10013) :61-69

[8] Chronic diseases 4 - Prevention of cardiovascular disease in high-risk individuals in low-income and middle-income countries: health effects and costs [J].

Lim, Stephen S. ;

Gaziano, Thomas A. ;

Gakidou, Emmanuela ;

Reddy, K. Srinath ;

Farzadfar, Farshad ;

Lozano, Rafael ;

Rodgers, Anthony .

LANCET, 2007, 370 (9604) :2054-2062

[9] A pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy ('polypill') on cardiovascular risk factors [J].

Malekzadeh, F. ;

Marshall, T. ;

Pourshams, A. ;

Gharravi, M. ;

Aslani, A. ;

Nateghi, A. ;

Rastegarpanah, M. ;

Khoshnia, M. ;

Semnani, S. ;

Salahi, R. ;

Thomas, G. N. ;

Larijani, B. ;

Cheng, K. K. ;

Malekzadeh, R. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2010, 64 (09) :1220-1227

[10] Polypill for Cardiovascular Disease Prevention in an Underserved Population [J].

Munoz, Daniel ;

Uzoije, Prince ;

Reynolds, Cassandra ;

Miller, Roslynn ;

Walkley, David ;

Pappalardo, Susan ;

Tousey, Phyllis ;

Munro, Heather ;

Gonzales, Holly ;

Song, Wenliang ;

White, Charles ;

Blot, William J. ;

Wang, Thomas J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (12) :1114-1123

← 1 2 3 4 →