Blood 'n' guts: an update on schistosome digestive peptidases

被引：128
作者：
Caffrey, CR [1 ]
McKerrow, JH [1 ]
Salter, JP [1 ]
Sajid, M [1 ]
机构：
[1] Univ Calif San Francisco, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94143 USA
来源：
TRENDS IN PARASITOLOGY | 2004年 / 20卷 / 05期
关键词：
D O I：
10.1016/j.pt.2004.03.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Peptidases (proteolytic enzymes) found in the gut of schistosomes digest host blood proteins and facilitate the maintenance of optimal nutritional and reproductive status. We review the latest information regarding these peptidases, including their individual biochemical and biophysical characteristics, and their possible interactions in vivo. The crucial issues of functional redundancy and suitability as drug targets are also discussed with respect to recent advances in genetic and chemical technologies.
引用
收藏
页码：241 / 248
页数：8
相关论文
共 73 条
  • [21] Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis:: the asparaginyl endopeptidase (Sm32)
    Chacón, N
    Losada, S
    Bermúdez, H
    Cesari, IM
    Hoebeke, J
    Noya, O
    [J]. IMMUNOLOGY LETTERS, 2003, 88 (03) : 199 - 210
  • [22] CHICHLIA K, 2002, PARASITOL RES, V88, P368
  • [23] DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni:: anti-fecundity effect induced in mice
    Chlichlia, K
    Bahgat, M
    Ruppel, A
    Schirrmacher, V
    [J]. VACCINE, 2001, 20 (3-4) : 439 - 447
  • [24] Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets
    Coombs, GH
    Goldberg, DE
    Klemba, M
    Berry, C
    Kay, J
    Mottram, JC
    [J]. TRENDS IN PARASITOLOGY, 2001, 17 (11) : 532 - 537
  • [25] Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing
    Dahl, SW
    Halkier, T
    Lauritzen, C
    Dolenc, I
    Pedersen, J
    Turk, V
    Turk, B
    [J]. BIOCHEMISTRY, 2001, 40 (06) : 1671 - 1678
  • [26] Asparaginyl endopeptidase activity in adult Schistosoma mansoni
    Dalton, JP
    HolaJamriska, L
    Brindley, PJ
    [J]. PARASITOLOGY, 1995, 111 : 575 - 580
  • [27] Schistosome asparaginyl endopeptidase Sm32 in hemoglobin digestion
    Dalton, JP
    Brindley, PJ
    [J]. PARASITOLOGY TODAY, 1996, 12 (03): : 125 - 125
  • [28] Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo:: W-hemorphin-7
    Fruitier, I
    Garreau, I
    Piot, JM
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 246 (03) : 719 - 724
  • [29] Chemical approaches for functionally probing the proteome
    Greenbaum, D
    Baruch, A
    Hayrapetian, L
    Darula, Z
    Burlingame, A
    Medzihradszky, KF
    Bogyo, M
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (01) : 60 - 68
  • [30] Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
    Greenbaum, D
    Medzihradszky, KF
    Burlingame, A
    Bogyo, M
    [J]. CHEMISTRY & BIOLOGY, 2000, 7 (08): : 569 - 581
12345678