Blood 'n' guts: an update on schistosome digestive peptidases

被引：128
作者：
Caffrey, CR [1 ]
McKerrow, JH [1 ]
Salter, JP [1 ]
Sajid, M [1 ]
机构：
[1] Univ Calif San Francisco, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94143 USA
来源：
TRENDS IN PARASITOLOGY | 2004年 / 20卷 / 05期
关键词：
D O I：
10.1016/j.pt.2004.03.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Peptidases (proteolytic enzymes) found in the gut of schistosomes digest host blood proteins and facilitate the maintenance of optimal nutritional and reproductive status. We review the latest information regarding these peptidases, including their individual biochemical and biophysical characteristics, and their possible interactions in vivo. The crucial issues of functional redundancy and suitability as drug targets are also discussed with respect to recent advances in genetic and chemical technologies.
引用
收藏
页码：241 / 248
页数：8
相关论文
共 73 条
  • [1] BASIC LOCAL ALIGNMENT SEARCH TOOL
    ALTSCHUL, SF
    GISH, W
    MILLER, W
    MYERS, EW
    LIPMAN, DJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
  • [2] Classification of the caspase-hemoglobinase fold: Detection of new families and implications for the origin of the eukaryotic separins
    Aravind, L
    Koonin, EV
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2002, 46 (04) : 355 - 367
  • [3] SPECIFICITY OF CATHEPSIN-B - HYDROLYSIS OF GLUCAGON AT C-TERMINUS BY A PEPTIDYL-DIPEPTIDASE MECHANISM
    ARONSON, NN
    BARRETT, AJ
    [J]. BIOCHEMICAL JOURNAL, 1978, 171 (03) : 759 - 765
  • [4] A novel cathepsin B active site motif is shared by helminth bloodfeeders
    Baig, S
    Damian, RT
    Peterson, DS
    [J]. EXPERIMENTAL PARASITOLOGY, 2002, 101 (2-3) : 83 - 89
  • [5] BARRETT A, 1998, PROTEOLYTIC ENZYMES
  • [6] Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, ''short'' pseudocathepsin D
    Beyer, BM
    Dunn, BM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (26) : 15590 - 15596
  • [7] Bogitsh BJ, 2001, J PARASITOL, V87, P237, DOI 10.1645/0022-3395(2001)087[0237:GAIOTS]2.0.CO
  • [8] 2
  • [9] Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
    Bogyo, M
    Verhelst, S
    Bellingard-Dubouchaud, V
    Toba, S
    Greenbaum, D
    [J]. CHEMISTRY & BIOLOGY, 2000, 7 (01): : 27 - 38
  • [10] Molecular modeling and substrate specificity of discrete cruzipain-like and cathepsin L-like cysteine proteinases of the human blood fluke Schistosoma mansoni
    Brady, CP
    Brinkworth, RI
    Dalton, JP
    Dowd, AJ
    Verity, CK
    Brindley, PJ
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 380 (01) : 46 - 55
12345678