Blood 'n' guts: an update on schistosome digestive peptidases

被引：129

作者：

Caffrey, CR ^{[1
]}

McKerrow, JH ^{[1
]}

Salter, JP ^{[1
]}

Sajid, M ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sandler Ctr Basic Res Parasit Dis, San Francisco, CA 94143 USA

来源：

TRENDS IN PARASITOLOGY | 2004年 / 20卷 / 05期

关键词：

D O I：

10.1016/j.pt.2004.03.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Peptidases (proteolytic enzymes) found in the gut of schistosomes digest host blood proteins and facilitate the maintenance of optimal nutritional and reproductive status. We review the latest information regarding these peptidases, including their individual biochemical and biophysical characteristics, and their possible interactions in vivo. The crucial issues of functional redundancy and suitability as drug targets are also discussed with respect to recent advances in genetic and chemical technologies.

引用

页码：241 / 248

页数：8

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