Enantioselective Intermolecular Crossed-Conjugate Additions between Nitroalkenes and α,β-Enals through a Dual Activation Strategy

被引：68

作者：

Zhong, Cheng ^{[1
]}

Chen, Yunfeng ^{[1
]}

Petersen, Jeffrey L. ^{[1
]}

Akhmedov, Novruz G. ^{[1
]}

Shi, Xiaodong ^{[1
]}

机构：

[1] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 07期

关键词：

asymmetric catalysis; enantioselectivity; Lewis bases; pyrrolidines; ASYMMETRIC-SYNTHESIS; MICHAEL ADDITION; ALDEHYDES; ORGANOCATALYSIS; STEREOCENTERS; CATALYSIS; PROLINE;

D O I：

10.1002/anie.200805558

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double the fun: The title reaction was developed by using a Lewis base/iminium activation strategy (see scheme). The reaction proceeded with excellent yields and ee values, and the products were additionally transformed into a single enantiomer of a substituted pyrrolidine with excellent retention of configuration. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1279 / 1282

页数：4

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