Matrilysin-2 expression in colorectal cancer is associated with overall survival of patients

被引：12

作者：

Hu, Qinglin ^{[1
]}

Yan, Chuanjing ^{[1
]}

Xu, Chengfei ^{[1
]}

Yan, Hai ^{[1
]}

Qing, Lian ^{[1
]}

Pu, Yanjun ^{[1
]}

He, Zeyou ^{[1
]}

Li, Xiaojun ^{[1
]}

机构：

[1] Chengdu Med Coll, Affiliated Hosp 1, Dept Gen Surg, Chengdu 610500, Sichuan, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 04期

关键词：

Matrilysin-2; Colorectal cancer; Immunohistochemistry; Prognosis; MATRIX METALLOPROTEINASE-26; TISSUE INHIBITORS; PROGNOSTIC VALUE; CARCINOMA; ENDOMETASE/MATRILYSIN-2; IDENTIFICATION; STATISTICS; ACTIVATION; INVASION; MMP-26;

D O I：

10.1007/s13277-013-1471-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor recurrence and metastasis are pressing issues of patients with colorectal cancer who receive surgery. Matrilysin-2 (MMP-26) has been proved to play an important role during invasion and metastasis of some human solid tumor. We aimed to investigate the clinical significance and prognostic value of matrilysin-2 in human colorectal cancer. Colorectal cancer and adjacent normal samples from 201 patients were collected. Matrilysin-2 expression level was investigated by immunohistochemistry assay, and its association with overall survival of patients was analyzed by statistical analysis. Results showed that matrilysin-2 expression level significantly elevated in colorectal cancer compared with adjacent normal specimens. Matrilysin-2 expression was also found to be associated with cancer invasion, lymph node metastasis, distant metastasis, and TNM stage. In addition, survival analysis showed that elevated matrilysin-2 expression was associated with poor overall survival of patients. Cox's proportional hazards model indicated that matrilysin-2 was an independent prognostic marker for patients with colorectal cancer. The present study found that the expression of matrilysin-2 increased in colorectal cancer and was associated with tumor progression. It also provided the first evidence that matrilysin-2 expression was an independent prognostic factor for patients with colorectal cancer, which might be a high specific biomarker for colorectal cancer.

引用

页码：3569 / 3574

页数：6

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