TRPC3 protein is expressed across the lifespan in human prefrontal cortex and cerebellum

被引：10

作者：

Roeddin, Angela S. ^{[1
,2
,3
]}

Gao, Andrew F. ^{[1
,2
]}

Wu, Alex M. L. ^{[1
,2
]}

Li, Peter P. ^{[1
,2
,4
]}

Kish, Stephen J. ^{[2
,4
,5
,6
]}

Warsh, Jerry J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Ctr Addict & Mental Hlth, Lab Cellular & Mol Pathophysiol, Toronto, ON M5T 1R8, Canada

[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada

[3] Univ Toronto, Program Neurosci, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada

[6] Ctr Addict & Mental Hlth, Human Neurochem Pathol Lab, Toronto, ON M5T 1R8, Canada

来源：

BRAIN RESEARCH | 2009年 / 1260卷

关键词：

Calcium signalling; TRPC3; Development; Bipolar disorder; Cerebellum; Prefrontal cortex; RECEPTOR POTENTIAL CHANNELS; B-LYMPHOBLASTS; NEUROTROPHIC FACTOR; BIPOLAR DISORDER; BASAL GANGLIA; BRAIN; LOCALIZATION; NEURONS;

D O I：

10.1016/j.brainres.2008.12.069

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The canonical transient receptor potential type 3 (TRPC3) channel is a non-selective, voltage-independent cation channel that is expressed in both excitable and non-excitable cells. As little is known regarding its presence in human brain and the influence of age on its expression, we examined TRPC3 protein expression by immunoblotting in postmortem prefrontal cortex and cerebellum obtained from subjects (8 days to 83 years) with no history of psychiatric or neurological disorder. The expression of TRPC3 protein in the prefrontal cortex (Brodmann area A9/A10) of the neonates/infants (<2 y) was significantly higher (25%) than that in the adolescent to adult (11y-83y) age group, whereas cerebellar TRPC3 levels showed no age-related changes. The results indicate that TRPC3 may be developmentally regulated in prefrontal cortex, and its expression in discrete human brain regions throughout the lifespan suggests a physiological role for TRPC3 during postnatal and adult life. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 22 条

[1] TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation [J].