Association of changes in cardiorespiratory fitness with health-related quality of life in young adults with mobility disability: secondary analysis of a randomized controlled trial of mobile app versus supervised training

BackgroundYoung adults with mobility disability report lower health-related quality of life (HRQoL) than their able-bodied peers. This study aims to examine potential differences between the effects of mobile app versus supervised training and the association of cardiorespiratory fitness change with HRQoL in young adults with mobility disability.MethodsThis is a secondary analysis of a parallel randomized controlled trial of a mobile app (n =55) and a supervised health program (n =55) that was provided for 12weeks to 110 adults (18-45years) with self-perceived mobility disability. Recruitment took place at rehabilitation centers in Stockholm, Sweden. Cardiorespiratory fitness was estimated from the results of a submaximal cycle ergometer test and HRQoL was assessed with the SF-36 questionnaire. Follow up was at 6weeks, 12weeks, and 1-year and all examinations were performed by blinded investigators. Between group differences of changes in HRQoL at follow up were estimated in intention-to-treat analysis using linear regression models. Crude and adjusted mixed-effects models estimated the associations between cardiorespiratory fitness change and HRQoL. Stratified analysis by intervention group was also performed.ResultsIn total, 40/55 from the mobile app group and 49/55 from the supervised training group were included in the intention to treat analysis. No significant differences were observed between the effects of the two interventions on HRQoL. In both crude and adjusted models, cardiorespiratory fitness change was associated with the general health (adjusted beta =1.30, 95% CI: 0.48, 2.13) and emotional role functioning (adjusted beta =1.18, 95% CI: 0.11, 2.25) domains of SF-36. After stratification, the associations with general health (adjusted beta =1.88, 95% CI: 0.87, 2.90) and emotional role functioning (adjusted beta =1.37, 95% CI: 0.18, 2.57) were present only in the supervised group.ConclusionThis study found positive associations between cardiorespiratory fitness change and HRQoL in young adults with mobility disability who received supervised training. The effects of mobile app versus supervised training on HRQoL remain unclear.Trial registrationInternational Standard Randomized Controlled Trial Number (ISRCTN) registry ISRCTN22387524; Prospectively registered on February 4th, 2018.