Diagnostic Criteria and Classification of Mastocytosis in 2014

被引：74

作者：

Akin, Cem ^{[1
]}

Valent, Peter ^{[2
,3
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Mastocytosis Ctr, Boston, MA 02115 USA

[2] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria

[3] Med Univ Vienna, Ludwig Boltzmann Cluster Oncol, A-1090 Vienna, Austria

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2014年 / 34卷 / 02期

关键词：

Mastocytosis; Diagnosis; Classification; World Health Organization; c-kit; Tryptase; MAST-CELL DISORDERS; C-KIT MUTATION; SYSTEMIC MASTOCYTOSIS; TRYPTASE LEVELS; SERUM TRYPTASE; SMOLDERING MASTOCYTOSIS; URTICARIA PIGMENTOSA; ACTIVATING MUTATION; HIGH PREVALENCE; WILD-TYPE;

D O I：

10.1016/j.iac.2014.02.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in response to various triggers. The diagnosis of mastocytosis should be made from objective pathologic findings. Modern diagnostic criteria and classification of mastocytosis were proposed in 2000 by an international consensus group and formed the basis of the current World Health Organization (WHO) guidelines, which have been validated to correlate with prognosis and help selection of therapy. In this article, the WHO criteria for diagnosis and classification are summarized and practical aspects to avoid common pitfalls in diagnostic workup are discussed.

引用

页码：207 / +

页数：13

共 68 条

[1] A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib [J].

Akin, C ;

Fumo, G ;

Yavuz, AS ;

Lipsky, PE ;

Neckers, L ;

Metcalfe, DD .

BLOOD, 2004, 103 (08) :3222-3225

[2] Systemic mastocytosis [J].

Akin, C ;

Metcalfe, DD .

ANNUAL REVIEW OF MEDICINE, 2004, 55 :419-432

[3] Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis [J].

Akin, C ;

Kirshenbaum, AS ;

Semere, T ;

Worobec, AS ;

Scott, LM ;

Metcalfe, DD .

EXPERIMENTAL HEMATOLOGY, 2000, 28 (02) :140-147

[4] The biology of Kit in disease and the application of pharmacogenetics [J].

Akin, C ;

Metcalfe, DD .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2004, 114 (01) :13-19

[5] Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit [J].

Akin, C ;

Brockow, K ;

D'Ambrosio, C ;

Kirshenbaum, AS ;

Ma, YS ;

Longley, BJ ;

Metcalfe, DD .

EXPERIMENTAL HEMATOLOGY, 2003, 31 (08) :686-692

[6] Multilineage hematopoietic involvement in systemic mastocytosis [J].

Akin, C .

LEUKEMIA RESEARCH, 2003, 27 (10) :877-878

[7] An immunohistochemical study of the bone marrow lesions of systemic mastocytosis - Expression of stem cell factor by lesional mast cells [J].

Akin, C ;

Jaffe, ES ;

Raffeld, M ;

Kirshenbaum, AS ;

Daley, T ;

Noel, P ;

Metcalfe, DD .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2002, 118 (02) :242-247

[8] Slowly progressive systemic mastocytosis with high mast-cell burden and no evidence of a non-mast-cell hematologic disorder: an example of a smoldering case? [J].

Akin, C ;

Scott, LM ;

Metcalfe, DD .

LEUKEMIA RESEARCH, 2001, 25 (07) :635-638

[9] Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with "idiopathic" anaphylaxis [J].

Akin, Cem ;

Scott, Linda M. ;

Kocabas, Can N. ;

Kushnir-Sukhov, Nataliya ;

Brittain, Erica ;

Noel, Pierre ;

Metcalfe, Dean D. .

BLOOD, 2007, 110 (07) :2331-2333

[10] Molecular diagnosis of mast cell disorders - A Paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology [J].

Akin, Cem .

JOURNAL OF MOLECULAR DIAGNOSTICS, 2006, 8 (04) :412-419

← 1 2 3 4 5 6 7 →