Physical map of the mouse λ light chain and related loci

被引：10

作者：

Gerdes, T ^{[1
]}

Wabl, M ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

IMMUNOGENETICS | 2002年 / 54卷 / 01期

关键词：

V(preB)1; V(preB)2; lambda; 5;

D O I：

10.1007/s00251-002-0435-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The lambda light chain genes and the related loci lambda5, V(preB)1 and V(preB)2 are selectively expressed in the development of B lymphocytes. The sequences and the order of the gene segments are known, but a precise physical map of the lambda locus has not yet been published. Using the Celera mouse genome database we constructed such a map. In this paper, we confirm the order of the gene segments as being Vlambda2 - VlambdaX - Jlambda2 - Clambda2 - Jlambda4 - Clambda4 - VlambdaI - Jlambda3 - Clambda3 - Jlambda1 - Clambda1 and give precise germ line distances. We located the V(preB)2 locus 3' to the lambda locus, 1,077,001 by downstream; the V(preB)1 locus, 2,180,618 by downstream of the lambda locus; and the 11,5 gene, 4,667 by downstream of the V(preB)1 locus. Except for the V(preB)2 locus all other loci are in the same transcriptional orientation.

引用

页码：62 / 65

页数：4

共 24 条

[1] SEQUENCES OF IMMUNOGLOBULIN-LAMBDA-1 GENES IN A LAMBDA-1 DEFECTIVE MOUSE STRAIN [J].

ARP, B ;

MCMULLEN, MD ;

STORB, U .

NATURE, 1982, 298 (5870) :184-187

[2] SEQUENCES OF MOUSE IMMUNOGLOBULIN LIGHT CHAIN GENES BEFORE AND AFTER SOMATIC CHANGES [J].

BERNARD, O ;

HOZUMI, N ;

TONEGAWA, S .

CELL, 1978, 15 (04) :1133-1144

[3] DNA-SEQUENCES OF THE JOINING REGIONS OF MOUSE LAMBDA-LIGHT CHAIN IMMUNOGLOBULIN GENES [J].

BLOMBERG, B ;

TONEGAWA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (02) :530-533

[4] ORGANIZATION OF 4 MOUSE LAMBDAL-LIGHT CHAIN IMMUNOGLOBULIN GENES [J].

BLOMBERG, B ;

TRAUNECKER, A ;

EISEN, H ;

TONEGAWA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3765-3769

[5] NATURAL ABUNDANCE OF LAMBDA-2-LIGHT CHAINS IN INBRED MICE [J].

COTNER, T ;

EISEN, HN .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 148 (05) :1388-1399

[6] The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development [J].

Dul, JL ;

Argon, Y ;

Winkler, T ;

tenBoekel, E ;

Melchers, F ;

Martensson, IL .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (04) :906-913

[7] THE EXPRESSION OF V-PRE-B/LAMBDA-5 SURROGATE LIGHT-CHAIN IN EARLY BONE-MARROW PRECURSOR B-CELLS OF NORMAL AND B-CELL-DEFICIENT MUTANT MICE [J].

KARASUYAMA, H ;

ROLINK, A ;

SHINKAI, Y ;

YOUNG, F ;

ALT, FW ;

MELCHERS, F .

CELL, 1994, 77 (01) :133-143

[8] ORGANIZATION OF THE MURINE IG-RELATED LAMBDA-5 GENE TRANSCRIBED SELECTIVELY IN LYMPHOCYTES-PRE-B [J].

KUDO, A ;

SAKAGUCHI, N ;

MELCHERS, F .

EMBO JOURNAL, 1987, 6 (01) :103-107

[9] A 2ND GENE, VPREB IN THE LAMBDA-5 LOCUS OF THE MOUSE, WHICH APPEARS TO BE SELECTIVELY EXPRESSED IN LYMPHOCYTES-PRE-B [J].

KUDO, A ;

MELCHERS, F .

EMBO JOURNAL, 1987, 6 (08) :2267-2272

[10] THE EXPRESSION OF THE MOUSE V PREB/LAMBDA-5 LOCUS IN TRANSFORMED-CELL LINES AND TUMORS OF THE B-LINEAGE DIFFERENTIATION PATHWAY [J].

KUDO, A ;

THALMANN, P ;

SAKAGUCHI, N ;

DAVIDSON, WF ;

PIERCE, JH ;

KEARNEY, JF ;

RETH, M ;

ROLINK, A ;

MELCHERS, F .

INTERNATIONAL IMMUNOLOGY, 1992, 4 (08) :831-840

← 1 2 3 →