Complexity of the TOR signaling network

被引：153

作者：

Inoki, K ^{[1
]}

Guan, KL ^{[1
]}

机构：

[1] Univ Michigan, Inst Gerontol, Dept Biol Chem, Inst Life Sci, Ann Arbor, MI 48109 USA

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tcb.2006.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The target of rapamycin (TOR) is a serine/threonine kinase of the phosphatidylinositol kinase-related kinase family and is highly conserved from yeast to mammals. TOR functions as a central regulator of cell growth and is itself regulated by a wide range of signals, including growth factors, nutrients and stress conditions. Recent studies in eukaryotic cells have identified two distinct TOR complexes, TORC1 and TORC2, which phosphorylate different substrates and have distinct physiological functions. Here, we discuss new findings that have extended the complexity of TOR signaling and the different roles of the TORC complexes in yeast, flies and mammals.

引用

页码：206 / 212

页数：7

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