Three new isoflavanones from Erythrina costaricensis

被引：13

作者：

Tanaka, Hitoshi ^{[1
]}

Hattori, Hisanori ^{[1
]}

Oh-Uchi, Tomoko ^{[1
]}

Sato, Masaru ^{[2
]}

Sako, Magoichi ^{[3
]}

Tateishi, Yoichi ^{[4
]}

Rizwani, Ghazala Hafeez ^{[5
]}

机构：

[1] Meijo Univ, Fac Pharm, Nagoya, Aichi 468, Japan

[2] Asahi Univ, Sch Dent, Dept Oral Pathol, Gifu, Japan

[3] Ohara Pharmaceut Co Ltd, Koka, Shiga, Japan

[4] Univ Ryukyus, Fac Educ, Okinawa, Japan

[5] Univ Karachi, Dept Pharmacognosy, Fac Pharm, Karachi, Pakistan

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 12期

关键词：

Erythrina costaricensis; Leguminosae; isoflavonoids; isoflavanones; anti-MRSA activity; CONSTITUENTS; ROOTS;

D O I：

10.1080/14786410802292286

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new isoflavanones, 5,7,3'-trihydroxy-4'-methoxy-6,5'-di(, -dimethylallyl)-isoflavanone (1), 5,3'-dihydroxy-4'-methoxy-5'-,-dimethylallyl-2'',2''-dimethylpyrano[5,6 : 6,7]isoflavanone (2) and 5,3'-dihydroxy-2'',2''-dimethylpyrano[5,6 : 6,7]-2''',2'''-dimethylpyrano[5,6 : 5,4]isoflavanone (3), along with two known isoflavonoids, cristacarpin and euchrenone b10, were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence. Compound 3 is a rare isoflavanone possessing two 2,2-dimethylpyran moieties. Among the new isoflavanones, compound 1 showed potent antibacterial activity against methicillin-resistant Staphylococcus aureus.

引用

页码：1089 / 1094

页数：6

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