Chemotherapeutic drugs - more really is not better

被引：99

作者：

Fidler, IJ ^{[1
]}

Ellis, LM ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Canc Biol 173, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 05期

关键词：

D O I：

10.1038/74969

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent insights into the molecular mechanisms that regulate the process of metastasis and the complex interactions between metastatic cells and host factors have provided a biological foundation for the design of more effective therapies.

引用

页码：500 / 502

页数：3

共 18 条

[1] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[2] ANGIOGENESIS INHIBITION - A REVIEW [J].

AUERBACH, W ;

AUERBACH, R .

PHARMACOLOGY & THERAPEUTICS, 1994, 63 (03) :265-311

[3]

BAKER CH, 2000, P AM ASSOC CANC RES, V41, P308

[4] Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal [J].

Benjamin, LE ;

Keshet, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8761-8766

[5]

Browder T, 2000, CANCER RES, V60, P1878

[6] INTERFERON ALFA-2A THERAPY FOR LIFE-THREATENING HEMANGIOMAS OF INFANCY [J].

EZEKOWITZ, RAB ;

MULLIKEN, JB ;

FOLKMAN, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (22) :1456-1463

[7]

FIDLER IJ, 1990, CANCER RES, V50, P6130

[8] MODULATION OF THE ORGAN MICROENVIRONMENT FOR TREATMENT OF CANCER METASTASIS [J].

FIDLER, IJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (21) :1588-1592

[9] METASTASIS RESULTS FROM PREEXISTING VARIANT CELLS WITHIN A MALIGNANT-TUMOR [J].

FIDLER, IJ ;

KRIPKE, ML .

SCIENCE, 1977, 197 (4306) :893-895

[10] Angiogenic zip code [J].

Folkman, J .

NATURE BIOTECHNOLOGY, 1999, 17 (08) :749-749

← 1 2 →