Schistosome-Induced Fibrotic Disease: The Role of Hepatic Stellate Cells

被引：74

作者：

Carson, Jack P. ^{[1
]}

Ramm, Grant A. ^{[2
,3
]}

Robinson, Mark W. ^{[1
]}

McManus, Donald P. ^{[2
]}

Gobert, Geoffrey N. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Biol Sci, Med Biol Ctr, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland

[2] Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Locked Bag 2000, Brisbane, Qld 4029, Australia

[3] Univ Queensland, Fac Med, Level 6,Oral Hlth Ctr Bldg,Herston Rd, Herston, Qld 4006, Australia

来源：

TRENDS IN PARASITOLOGY | 2018年 / 34卷 / 06期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

TISSUE GROWTH-FACTOR; MAJOR EGG ANTIGEN; FACTOR-BETA RESPONSE; HEAT-SHOCK PROTEINS; TGF-BETA; LIVER FIBROSIS; MANSONI EGGS; RAT-LIVER; IN-VIVO; NONALCOHOLIC STEATOHEPATITIS;

D O I：

10.1016/j.pt.2018.02.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Hepatic fibrosis is a common pathology in various liver diseases. Hepatic stellate cells (HSCs) are the main cell type responsible for collagen deposition and fibrosis formation in the liver. Schistosomiasis is characterised by granulomatous fibrosis around parasite eggs trapped within the liver and other host tissues. This response is facilitated by the recruitment of immune cells and the activation of HSCs. The interactions between HSCs and schistosome eggs are complex and diverse, and a better understanding of these interactions could lead to improved resolution of fibrotic liver disease, including that associated with schistosomiasis. Here, we discuss recent advances in HSC biology and the role of HSCs in hepatic schistosomiasis.

引用

页码：524 / 540

页数：17

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