Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism

被引：423

作者：

Elia, Ilaria ^{[1
,2
]}

Haigis, Marcia C. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Dept Cell Biol, Blavatnik Inst, Boston, MA 02115 USA

[2] Harvard Med Sch, Ludwig Canc Ctr, Boston, MA 02115 USA

来源：

NATURE METABOLISM | 2021年 / 3卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HUMAN PANCREATIC-CANCER; REGULATORY T-CELLS; AEROBIC GLYCOLYSIS; GLUTAMINE-METABOLISM; GENE-EXPRESSION; INDOLEAMINE 2,3-DIOXYGENASE; GLUCOSE DEPRIVATION; EFFECTOR FUNCTION; T-HELPER-1; CELL; IMMUNE CELLS;

D O I：

10.1038/s42255-020-00317-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The tumour microenvironment (TME) is a unique cellular and metabolic landscape. Elia and Haigis describe how metabolism influences, and is affected by, the complexity of cellular interactions within the TME and highlight opportunities for therapeutic intervention. Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy. Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as metabolite availability in the tumour microenvironment (TME). This metabolic niche within the TME is shaped by four tiers of regulation: (1) intrinsic tumour cell metabolism, (2) interactions between cancer cells and non-cancerous cells, (3) tumour location and heterogeneity and (4) whole-body metabolic homeostasis. Here, we define these modes of metabolic regulation and review how distinct cell types contribute to the metabolite composition of the TME. Finally, we connect these insights to understand how each of these tiers offers unique therapeutic potential to modulate the metabolic profile and function of all cells inhabiting the TME.

引用

页码：21 / 32

页数：12

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