Antihyperglycemic, Hypolipidemic and Antioxidant Enzymes Effect of Strobilanthes crispus Juice in Normal and Streptozotocin-Induced Diabetic Male and Female Rats

被引:10
作者
Norfarizan-Hanoon, N. A. [1 ]
Asmah, R. [2 ]
Rokiah, M. Y. [2 ]
Fauziah, O. [3 ]
Faridah, H. [4 ]
机构
[1] Univ Sains Malaysia, Sch Hlth Sci, Kubang Kerian 16150, Kelantan, Malaysia
[2] Univ Putra Malaysia, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia
[3] Univ Putra Malaysia, Dept Human Anat, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia
[4] Malaysian Agr Res & Dev Inst, Serdang, Selangor, Malaysia
关键词
Strobilanthes crispus juice; glucose; lipid profile; antioxidant;
D O I
10.3923/ijp.2009.200.207
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The aim of the present study was to investigate the effect of Strobilanthes crispus juice on glucose, lipid profile, glutathione peroxidase and superoxide dismutase in normal and streptozotocin-induced diabetic male and female albino Sprague-Dawley rats. This study was conducted on normal and streptozotocin-induced diabetic male and female Sprague-Dawley rats fed with basal diet and S. crispus juice with different doses 1.0, 1.5 and 2.0 mL kg(-1) b.wt. for 30 days. The results showed that significant (p<0.05) decrease in serum glucose levels in male and female diabetic and normal rats with treated S. crispus juice (1.0, 1.5 and 2.0 mL kg(-1) b.wt.). Cholesterol and triglyceride level significantly (p<0.05) decreased in diabetic rats treated with 1.0, 1.5 and 2.0 mL kg(-1) b.wt. of S. crispus juice. Cholesterol, triglyceride and LDL-cholesterol level showed reduction in treated male and female normal rats. HDL-cholesterol showed the increasing but not significant (p<0.05) difference in treated diabetic and normal male and female rats. Glutathione peroxidase and superoxide dismutase activities significantly (p<0.05) increased in treated diabetic and normal male and female rats. In conclusion, S. crispus juice possesses antihyperglycemic, hypolipidemic and antioxidant effect in streptozotocin-induced diabetic rats. Thus, S. crispus juice could be the alternative treatment for lowering glucose, cholesterol and triglyceride for diabetic patients in the future.
引用
收藏
页码:200 / 207
页数:8
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