Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT

被引：3

作者：

Yaglova, N. V. ^{[1
]}

Tsomartova, D. A. ^{[1
]}

Obernikhin, S. S. ^{[1
]}

Nazimova, S. V. ^{[1
]}

Yaglov, V. V. ^{[1
]}

机构：

[1] Res Inst Human Morphol, Lab Endocrine Syst Dev, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 03期

关键词：

PRH; adrenal gland; proliferation; DDT; endocrine disrupter; DICHLORODIPHENYLTRICHLOROETHANE DDT;

D O I：

10.1007/s10517-019-04537-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of endocrine disrupters of transcriptional control of morphogenesis are poorly studied. Changes in the expression of transcriptional factor PRH and proliferation of adrenal cortical cells were analyzed in pubertal and postpubertal rats exposed prenatally and postnatally to low doses of endocrine disrupter DDT. In rats exposed to DDT, the expression of PRH and proliferation of adrenal cortical cells differed from those in control rats. Association between these parameters was weakened in the zona glomerulosa and zona reticularis and was absent in the zona fasciculata. These findings suggest that exposure to DDT in pre- and postnatal periods impairs the regulation of proliferative processes by transcriptional factor PRH in all zones of rat adrenal cortex, which can be a mechanism of the disruptive action of DDT.

引用

页码：404 / 407

页数：4

共 8 条

[1] Regulation of Proliferative Processes in Rat Adrenal Cortex by Transcriptional Factor PRH under Conditions of Developmental Exposure to Endocrine Disruptor DDT
N. V. Yaglova
D. A. Tsomartova
S. S. Obernikhin
S. V. Nazimova
V. V. Yaglov
Bulletin of Experimental Biology and Medicine, 2019, 167 : 404 - 407
[2] Low-Dose Exposure to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) Affects Transcriptional Regulation of Adrenal Zona Reticularis in Male Rats
Yaglova, N. V.
Obernikhin, S. S.
Yaglov, V. V.
Nazimova, S. V.
Timokhina, E. P.
Tsomartova, D. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2021, 170 (05) : 682 - 685
[3] Low-Dose Exposure to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) Affects Transcriptional Regulation of Adrenal Zona Reticularis in Male Rats
N. V. Yaglova
S. S. Obernikhin
V. V. Yaglov
S. V. Nazimova
E. P. Timokhina
D. A. Tsomartova
Bulletin of Experimental Biology and Medicine, 2021, 170 : 682 - 685
[4] Developmental Exposure to DDT Disrupts Transcriptional Regulation of Postnatal Growth and Cell Renewal of Adrenal Medulla
Yaglova, Nataliya V.
Nazimova, Svetlana V.
Obernikhin, Sergey S.
Tsomartova, Dibakhan A.
Yaglov, Valentin V.
Timokhina, Ekaterina P.
Tsomartova, Elina S.
Chereshneva, Elizaveta V.
Ivanova, Marina Y.
Lomanovskaya, Tatiana A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
[5] Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes
Yaglova, N. V.
Obernikhin, S. S.
Tsomartova, D. A.
Nazimova, S. V.
Yaglov, V. V.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 165 (04) : 508 - 511
[6] Expression of Transcription Factor PRH/Hhex in Adrenal Chromaffin Cells in the Postnatal Development and Its Role in the Regulation of Proliferative Processes
N. V. Yaglova
S. S. Obernikhin
D. A. Tsomartova
S. V. Nazimova
V. V. Yaglov
Bulletin of Experimental Biology and Medicine, 2018, 165 : 508 - 511
[7] Developmental exposure to endocrine disrupter dichlorodiphenyltrichloroethane alters transcriptional regulation of postnatal morphogenesis of adrenal zona fasciculata
Yaglova, Nataliya
Obernikhin, Sergey
Nazimova, Svetlana
Yaglov, Valentin
SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2020, 27 (12) : 3655 - 3659
[8] REGULATION OF ALBUMIN EXPRESSION IN FETAL-RAT HEPATOCYTES CULTURED UNDER PROLIFERATIVE CONDITIONS - ROLE OF EPIDERMAL GROWTH-FACTOR AND HORMONES
DEJUAN, C
BENITO, M
FABREGAT, I
JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 152 (01) : 95 - 101

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