Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl-Bis(benzamidine) Components

被引：23

作者：

Sanchez, Mateo I. ^{[1
,2
]}

Mosquera, Jesus ^{[1
,2
]}

Eugenio Vazquez, M. ^{[1
,2
]}

Mascarenas, Jose L. ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Ctr Singular Invest Quim Biol & Mat Mol CIQUS, Santiago De Compostela 15782, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 37期

基金：

欧洲研究理事会;

关键词：

DNA recognition; minor-groove binders; peptides; self-assembly; supramolecular chemistry; CRYSTAL-STRUCTURE; HIGH-AFFINITY; RECOGNITION; SEQUENCE; PROTEIN; TRANSITION; COMPLEX; GCN4; MODULATION; RESIDUES;

D O I：

10.1002/anie.201405726

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.

引用

页码：9917 / 9921

页数：5