On the polymorphism of benzocaine; a low-temperature structural phase transition for form (II)

被引：30

作者：

Chan, Eric J. ^{[1
]}

Rae, A. David ^{[1
]}

Welberry, T. Richard ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

来源：

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE | 2009年 / 65卷

基金：

澳大利亚研究理事会;

关键词：

LOCAL-ANESTHETIC DRUGS; CRYSTAL POLYMORPHISM;

D O I：

10.1107/S0108768109018898

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A low-temperature structural phase transition has been observed for form (II) of benzocaine (BZC). Lowering the temperature doubles the b-axis repeat and changes the space group from P2(1)2(1)2(1) to P112(1) with gamma now 99.37 degrees. The structure is twinned, the twin rule corresponding to a 21 screw rotation parallel to a. The phase transition is associated with a sequential displacement parallel to a of zigzag bi-layers of ribbons perpendicular to b*. No similar phase transition was observed for form (I) and this was attributed to the different packing symmetries of the two room-temperature polymorphic forms.

引用

页码：509 / 515

页数：7

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