Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles for CGFS glutaredoxins and BolA proteins

被引：42

作者：

Talib, Evan A. ^{[1
]}

Outten, Caryn E. ^{[1
]}

机构：

[1] Univ South Carolina, Dept Chem & Biochem, Columbia, SC 29205 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2021年 / 1868卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Glutaredoxin; BolA; Iron-sulfur cluster biogenesis; Iron homeostasis; Iron regulation; Glutathione; FE-S CLUSTER; MONOTHIOL GLUTAREDOXINS; SACCHAROMYCES-CEREVISIAE; STRUCTURAL INSIGHTS; MOLECULAR-MECHANISM; RESPIRATORY-CHAIN; 4FE-4S CLUSTERS; 2FE-2S; COMPLEX; MATURATION;

D O I：

10.1016/j.bbamcr.2020.118847

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and trafficking of iron-sulfur (Fe-S) clusters in both prokaryotes and eukaryotes requires co-ordination within an expanding network of proteins that function in the cytosol, nucleus, mitochondria, and chloroplasts in order to assemble and deliver these ancient and essential cofactors to a wide variety of Fe-S-dependent enzymes and proteins. This review focuses on the evolving roles of two ubiquitous classes of proteins that operate in this network: CGFS glutaredoxins and BolA proteins. Monothiol or CGFS glutaredoxins possess a Cys-Gly-Phe-Ser active site that coordinates an Fe-S cluster in a homodimeric complex. CGFS glutaredoxins also form [2Fe-2S]-bridged heterocomplexes with BolA proteins, which possess an invariant His and an additional His or Cys residue that serve as cluster ligands. Here we focus on recent discoveries in bacteria, fungi, humans, and plants that highlight the shared and distinct roles of CGFS glutaredoxins and BolA proteins in Fe-S cluster biogenesis, Fe-S cluster storage and trafficking, and Fe-S cluster signaling to transcriptional factors that control iron metabolism-.

引用

页数：16

共 118 条

[11] Glutathione, Glutaredoxins, and Iron [J].

Berndt, Carsten ;

Lillig, Christopher Horst .

ANTIOXIDANTS & REDOX SIGNALING, 2017, 27 (15) :1235-1251

[12] Formation of [4Fe-4S] Clusters in the Mitochondrial Iron-Sulfur Cluster Assembly Machinery [J].

Brancaccio, Diego ;

Gallo, Angelo ;

Mikolajczyk, Maciej ;

Zovo, Kairit ;

Palumaa, Peep ;

Novellino, Ettore ;

Piccioli, Mario ;

Ciofi-Baffoni, Simone ;

Banci, Lucia .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (46) :16240-16250

[13] Molecular Basis of the Regulation of Iron Homeostasis in Fission and Filamentous Yeasts [J].

Brault, Ariane ;

Mourer, Thierry ;

Labbe, Simon .

IUBMB LIFE, 2015, 67 (11) :801-815

[14] Evidence for Network Evolution in an Arabidopsis Interactome Map [J].

Braun, Pascal ;

Carvunis, Anne-Ruxandra ;

Charloteaux, Benoit ;

Dreze, Matija ;

Ecker, Joseph R. ;

Hill, David E. ;

Roth, Frederick P. ;

Vidal, Marc ;

Galli, Mary ;

Balumuri, Padmavathi ;

Bautista, Vanessa ;

Chesnut, Jonathan D. ;

Kim, Rosa Cheuk ;

de los Reyes, Chris ;

Gilles, Patrick, II ;

Kim, Christopher J. ;

Matrubutham, Uday ;

Mirchandani, Jyotika ;

Olivares, Eric ;

Patnaik, Suswapna ;

Quan, Rosa ;

Ramaswamy, Gopalakrishna ;

Shinn, Paul ;

Swamilingiah, Geetha M. ;

Wu, Stacy ;

Ecker, Joseph R. ;

Dreze, Matija ;

Byrdsong, Danielle ;

Dricot, Amelie ;

Duarte, Melissa ;

Gebreab, Fana ;

Gutierrez, Bryan J. ;

MacWilliams, Andrew ;

Monachello, Dario ;

Mukhtar, M. Shahid ;

Poulin, Matthew M. ;

Reichert, Patrick ;

Romero, Viviana ;

Tam, Stanley ;

Waaijers, Selma ;

Weiner, Evan M. ;

Vidal, Marc ;

Hill, David E. ;

Braun, Pascal ;

Galli, Mary ;

Carvunis, Anne-Ruxandra ;

Cusick, Michael E. ;

Dreze, Matija ;

Romero, Viviana ;

Roth, Frederick P. .

SCIENCE, 2011, 333 (6042) :601-607

[15] Iron-sulfur cluster biogenesis and trafficking in mitochondria [J].

Braymer, Joseph J. ;

Lill, Roland .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (31) :12754-12763

[16] Iron-sulfur cluster carrier proteins involved in the assembly of Escherichia coli NADH:ubiquinone oxidoreductase (complex I) [J].

Burschel, Sabrina ;

Decovic, Doris Kreuzer ;

Nuber, Franziska ;

Stiller, Marie ;

Hofmann, Maud ;

Zupok, Arkadiusz ;

Siemiatkowska, Beata ;

Gorka, Michal ;

Leimkuehler, Silke ;

Friedrich, Thorsten .

MOLECULAR MICROBIOLOGY, 2019, 111 (01) :31-45

[17] The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload [J].

Camaschella, Clara ;

Campanella, Alessandro ;

De Falco, Luigia ;

Boschetto, Loredana ;

Merlini, Roberta ;

Silvestri, Laura ;

Levi, Sonia ;

Iolascon, Achille .

BLOOD, 2007, 110 (04) :1353-1358

[18] Mutations in Iron-Sulfur Cluster Scaffold Genes NFU1 and BOLA3 Cause a Fatal Deficiency of Multiple Respiratory Chain and 2-Oxoacid Dehydrogenase Enzymes [J].

Cameron, Jessie M. ;

Janer, Alexandre ;

Levandovskiy, Valeriy ;

MacKay, Nevena ;

Rouault, Tracey A. ;

Tong, Wing-Hang ;

Ogilvie, Isla ;

Shoubridge, Eric A. ;

Robinson, Brian H. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2011, 89 (04) :486-495

[19] GLRX3 Acts as a [2Fe-2S] Cluster Chaperone in the Cytosolic Iron- Sulfur Assembly Machinery Transferring [2Fe-2S] Clusters to NUBP1 [J].

Camponeschi, Francesca ;

Prusty, Nihar Ranjan ;

Heider, Sabine Annemarie Elisabeth ;

Ciofi-Baffoni, Simone ;

Banci, Lucia .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (24) :10794-10805

[20] Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3 [J].

Chi, Chang-Biao ;

Tang, YaJun ;

Zhang, Jiahai ;

Dai, Ya-Nan ;

Abdalla, Mohnad ;

Chen, Yuxing ;

Zhou, Cong-Zhao .

JOURNAL OF MOLECULAR BIOLOGY, 2018, 430 (08) :1235-1248

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