Synthesis, characterization and cytotoxic activity of new platinum(II) complexes with some nitrogen containing ligands .2. With 3,5-dimethylpyrazole

New platinum(II) complexes of the general formula cis-[PtLL'X(2)], where L = L' = 3,5-dimethylpyrazole, X = 0.5 C2O4 or 0.5 O-2(CO)(2)C-CH2CH2CH2CH2 or O(CO)C6H11 and L = 3,5-dimethylpyrazole, L' = DMSO, X = Cl, have been prepared as analogue to so called cisplatin, carboplatin (paraplatin) and oxaliplatin; the known, anti-cancer drugs. The complexes obtained have been characterized physico-chemically and spectroscopically. The cytotoxic activities of these complexes have been studied against Hep-2, HeLa, RD, L(20B), BGM and Vero cell lines using the MTT-colorimetric assay. These activities were compared with cytotoxic activities of three reference standards: the cisplatin, carboplatin and oxaliplatin complexes: The significance of the results obtained is discussed.