Synthesis and Antimicrobial Activities of 2,5-Substituent Hydroquinone Derivatives

被引：3
作者：
Liu, Hui-Lian [1 ]
Wang, Qing-Zhong [1 ]
机构：
[1] Weifang Univ, Key Lab Biochem & Mol Biol Univ Shandong, Coll Biol & Agr Engn, Weifang 261061, Shandong, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 16期
关键词：
Hydroquinone derivatives; Antimicrobial activities; Structure-activity relationships; AMINE OXIDASES;
D O I：
10.14233/ajchem.2014.16585
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2,5-substituent hydroquinone derivatives were designed and synthesized. Their structures were identified by elemental analysis, H-1 NMR, IR spectra. Their assayed antibacterial (Escherichia coli, Bacillus subtilis) and antifungal (Candida albicans) activities were also evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The results of biological test showed compounds 1 and 10 have favorable antimicrobial activity with MICs of 20.5, 24.6, 18.9 and 28.6 mu g/mL against Escherichia coli and Bacillus subtilis, respectively.
引用
收藏
页码：5165 / 5167
页数：3
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