Differentiating attention-deficit/hyperactivity disorder inattentive and combined types: a 1H-magnetic resonance spectroscopy study of fronto-striato-thalamic regions

被引：32

作者：

Ferreira, Pedro E. M. S. ^{[1
]}

Palmini, André ^{[1
]}

Bau, Claiton H. D. ^{[2
]}

Grevet, Eugenio Horacio ^{[3
]}

Hoefel, Joao Rubiao ^{[4
]}

Rohde, Luis Augusto ^{[3
]}

Anes, Mauricio ^{[4
]}

Ferreira, Eloisa Elena ^{[1
]}

Belmonte-de-Abreu, Paulo ^{[3
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, HSL, Serv Psiquiatria, Grad Program Neurosci & Neurol & Psychiat Serv, BR-90610000 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS, Brazil

[4] Pontificia Univ Catolica Rio Grande do Sul, HSL, CDI, Porto Alegre, RS, Brazil

来源：

JOURNAL OF NEURAL TRANSMISSION | 2009年 / 116卷 / 05期

关键词：

Attention-deficit/hyperactivity disorder; Neuroimaging; Spectroscopy; Inattention; Hyperactivity; Diagnosis; DEFICIT-HYPERACTIVITY DISORDER; DSM-IV SUBTYPES; BIPOLAR DISORDER; ADHD SUBTYPES; CHILDREN; ADOLESCENTS; INHIBITION; DYSFUNCTION; PREVALENCE; CHOLINE;

D O I：

10.1007/s00702-009-0191-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite the implication of fronto-striatal circuits in attention-deficit/hyperactivity disorder (ADHD), there is a lack of information on the role of these regions, especially the thalamus, in the heterogeneity of ADHD. We assessed the H-1-magnetic resonance spectroscopy profile in ventromedial prefrontal cortex (VMPFC)-thalamic-striatal regions bilaterally in three groups of subjects (age range 18-24 years old): ADHD inattentive type (ADHD-I; n = 9), ADHD combined type (ADHD-C; n = 10) and non-ADHD controls (n = 12). The peaks of N-acetylaspartate, Choline (Cho), myo-inositol (mI), creatine (Cr) and glutamate-glutamine-GABA (Glx) to Cr were calculated. Subjects with ADHD-C showed lower mI/Cr ratio in the right VMPFC than controls, higher Cho/Cr ratio in the left thalamus-pulvinar than the ADHD-I group and higher Glx/Cr ratio in left putamen than individuals with ADHD-I and controls. This metabolic profile suggests a disruption of fronto-striato-thalamic structures in the ADHD-C as a result of lower neuronal energetic metabolism.

引用

页码：623 / 629

页数：7

共 39 条

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