β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway

被引：45

作者：

Gao, Huijie ^{[1
,2
]}

Peng, Cheng ^{[1
,2
]}

Liang, Benjia ^{[1
,2
]}

Shahbaz, Muhammad ^{[1
,2
]}

Liu, Song ^{[3
]}

Wang, Ben ^{[1
,2
]}

Sun, Qi ^{[1
,2
]}

Niu, Zhengchuan ^{[1
,2
]}

Niu, Weibo ^{[1
]}

Liu, Enyu ^{[1
]}

Wang, Jiayong ^{[1
]}

Lin, Pengfei ^{[1
]}

Wang, Jian ^{[4
]}

Niu, Jun ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Dept Hepatobiliary Surg, Jinan 250012, Shandong, Peoples R China

[2] Chinese Minist Educ & Publ Hlth, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China

[3] Binzhou Med Coll, Affiliated Hosp, Dept Thyroid & Breast Surg, Binzhou 256603, Shandong, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Surg Oncol, Hangzhou 310009, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2014年 / 354卷 / 02期

关键词：

beta; 6; integrin; Colon cancer; ETS1; MATRIX METALLOPROTEINASES; ALPHA-V-BETA-6; INTEGRIN; RNA INTERFERENCE; MIGRATION; PROMOTES; BINDING; MATRIX-METALLOPROTEINASE-9; DEGRADATION; MECHANISMS; SECRETION;

D O I：

10.1016/j.canlet.2014.08.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We previously reported that beta 6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that beta 6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that beta 6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：427 / 437

页数：11

共 44 条

[1] THE ALPHA-V-BETA-6 INTEGRIN PROMOTES PROLIFERATION OF COLON-CARCINOMA CELLS THROUGH A UNIQUE REGION OF THE BETA-6 CYTOPLASMIC DOMAIN [J].