Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

被引：48

作者：

Winter, Amanda L. ^{[1
]}

Conklin, Heather M. ^{[2
]}

Tyc, Vida L. ^{[2
]}

Stancel, Heather ^{[1
]}

Hinds, Pamela S. ^{[3
,4
]}

Hudson, Melissa M. ^{[5
]}

Kahalley, Lisa S. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Psychol Sect, Houston, TX 77030 USA

[2] St Jude Childrens Res Hosp, Dept Psychol, Memphis, TN 38105 USA

[3] Childrens Natl Hlth Syst, Dept Nursing Res & Qual Outcomes, Washington, DC USA

[4] George Washington Univ, Dept Pediat, Washington, DC 20052 USA

[5] St Jude Childrens Res Hosp, Div Canc Survivorship, Dept Oncol, Memphis, TN 38105 USA

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2014年 / 36卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Late effects; Brain tumor; Executive function; Leukemia; Pediatric; LONG-TERM SURVIVORS; CONFORMAL RADIATION-THERAPY; CHILDHOOD-CANCER; WORKING-MEMORY; NEUROCOGNITIVE SEQUELAE; DEVELOPMENTAL MODEL; PROCESSING SPEED; RISK-FACTORS; DOUBLE-BLIND; ATTENTION;

D O I：

10.1080/13803395.2014.943695

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: Survivors of pediatric brain tumors (BT) and acute lymphoblastic leukemia (ALL) are at risk for neurocognitive late effects related to executive function. Procedure: Survivors of BT (48) and ALL (50) completed neurocognitive assessment. Executive function was compared to estimated IQ and population norms by diagnostic group. Results: Both BT and ALL demonstrated relative executive function weaknesses. As a group, BT survivors demonstrated weaker executive functioning than expected for age. Those BT survivors with deficits exhibited a profile suggestive of global executive dysfunction, while affected ALL survivors tended to demonstrate specific rapid naming deficits. Conclusion: Findings suggest that pediatric BT and ALL survivors may exhibit different profiles of executive function late effects, which may necessitate distinct intervention plans.

引用

页码：818 / 830

页数：13

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