Mimicking Biological Delivery Through Feed back-Controlled Drug Release Systems Based on Molecular Imprinting

被引：52
|
作者：
Kryscio, David R. [1 ]
Peppas, Nicholas A. [1 ,2 ]
机构：
[1] Univ Texas Austin, Dept Chem Engn, Cockrell Sch Engn, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Biomed Engn, Cockrell Sch Engn, Austin, TX 78712 USA
来源：
AICHE JOURNAL | 2009年 / 55卷 / 06期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
molecularly imprinted polymers; drug delivery; feedback controlled release; hydrogels; environmentally responsive; SOFT CONTACT-LENSES; SOLID-PHASE EXTRACTION; BOVINE SERUM-ALBUMIN; POLY(N-ISOPROPYLACRYLAMIDE-CO-METHACRYLIC ACID) HYDROGELS; ENANTIOSELECTIVE-CONTROLLED DELIVERY; CATIONIC COPOLYMER HYDROGELS; PROTEIN RECOGNITION; GLUCOSE-OXIDASE; ARTIFICIAL ANTIBODIES; MACROPOROUS POLYMERS;
D O I：
10.1002/aic.11779
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Intelligent drug delivery systems (DDS) are able to rapidly detect a biological event and respond appropriately by releasing a therapeutic agent: thus. they are advantageous over their conventional counterparts. Molecular imprinting is a promising area that generates a polymeric network which can selectively recognize a desired anal-we. This field has been studied for a variety of applications over a long period of time, but only recently has it been investigated for biomedical and pharmaceutical applications. Recent work in the area of molecularly imprinted polymers in drug delivery highlights the potential of these recognitive networks as environmentally responsive DDS that can ultimately lead to feedback controlled recognitive release systems. (C) 2009 American Institute of Chemical Engineers AIChE J, 55: 1311-1324. 2009
引用
收藏
页码：1311 / 1324
页数：14
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