Thrombosis and platelets: an update

被引：414
作者：
Koupenova, Milka [1 ]
Kehrel, Beate E. [2 ]
Corkrey, Heather A. [1 ]
Freedman, Jane E. [1 ]
机构：
[1] Univ Massachusetts, Albert Sherman Ctr, Sch Med, 368 Plantat St, Worcester, MA 01605 USA
[2] Westfal Wilhelms Univ Muenster, Univ Hosp, Dept Anaesthesiol Intens Care & Pain Med, Expt & Clin Haemostasis Res, Mendelstr 11, D-48149 Munster, Germany
来源：
EUROPEAN HEART JOURNAL | 2017年 / 38卷 / 11期
关键词：
Platelets; Thrombosis; Coagulation; Cardiovascular; Bleeding; CARDIOVASCULAR RISK-FACTORS; VENOUS THROMBOEMBOLISM; MYOCARDIAL-INFARCTION; EUROPEAN-SOCIETY; ISCHEMIC-STROKE; SOLUBLE FIBRIN; INFECTION; ATHEROSCLEROSIS; ASSOCIATION; THERAPY;
D O I：
10.1093/eurheartj/ehw550
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Haemostasis and thrombosis are complex, multifactorial processes. There is an evolving understanding of the mechanisms influencing vascular occlusion and the role of inflammation and immunity. Despite major advances in elucidating the mechanistic pathways mediating platelet function and thrombosis, challenges in the treatment of vascular occlusive diseases persist. Pharmacological advances have greatly affected thrombotic outcomes, but this has led to the unwanted side effect of bleeding. Detailed assessment of the impact of non-thrombotic diseases on haemostasis and thrombosis is necessary to better evaluate thrombotic risk and establish optimal treatment. This review will focus on recent advances in understanding the contribution of evolving risk factors to thrombosis.
引用
收藏
页码：785 / 791
页数：7
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