Pharmacokinetics of 10B-p-boronophenylalanine (BPA) in the blood and tumors in human patients: A critical review with special reference to tumor-to-blood (T/B) ratios using resected tumor samples

被引：16

作者：

Fukuda, Hiroshi ^{[1
]}

Hiratsuka, Junichi ^{[2
]}

机构：

[1] Tohoku Med & Pharmaceut Univ, Dept Radiol, Miyagino Ku, Fukumuro 1-15-1, Sendai, Miyagi 9838536, Japan

[2] Kawasaki Med Sch, Dept Radiat Oncol, Okayama 7010192, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2020年 / 166卷 / 166期

关键词：

BNCT; B-10-p-boronophenylalanine (BPA); Pharmacokinetics; Blood; Tumor; T/B ratio; NEUTRON-CAPTURE THERAPY; GLIOBLASTOMA-MULTIFORME; BIODISTRIBUTION; MELANOMA; HEAD; NECK;

D O I：

10.1016/j.apradiso.2020.109308

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We reviewed B-10 concentration kinetics in the blood and tumors in human patients administered with BPA. The B-10 concentration in the blood peaked at the end of intravenous infusion of BPA, followed by a biphasic-decreasing curve with half-lives for the first and second components of the curve being 0.7-3.7 and 7.2-12.0 h, respectively. The mean tumor-to-blood (T/B) ratio obtained from resected tumor samples was 3.40 +/- 0.83 for melanoma and the ratio ranged from 1.4 to 4.7 for glioblastoma.

引用

页数：5

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