Asymmetric transfer hydrogenation of aromatic ketones with chiral diamino-thiophene/iridium catalyst systems

被引：12

作者：

Zhang, Xue-Qin

Li, Yan-Yun

Dong, Zhen-Rong

Shen, Wei-Yi

Cheng, Zhi-Bo

Gao, Jing-Xing ^{[1
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Fujian, Peoples R China

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2009年 / 307卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Thiophene ligands; Asymmetric transfer hydrogenation; Aromatic ketone; Chiral alcohols; TRANSITION-METAL-COMPLEXES; COORDINATION CHEMISTRY; RUTHENIUM COMPLEXES; LIGANDS; ALCOHOLS;

D O I：

10.1016/j.molcata.2009.03.019

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The chiral diamino-bis(bithiophene) ligands were firstly employed in the irridium(I)-catalyzed asymmetric transfer hydrogenation of aromatic ketones. The new catalyst systems, generated in situ from chiral diamino-bis(bithiophene) ligands and IrCl(CO)(PPh3)(2) in (PrOH)-Pr-i, gave the corresponding optically active secondary alcohols with high yield and fair to good enantioselectivities (up to 90% ee). The chiral Ir(I)/diamino-bis(bithiophene) complexes were also synthesized and characterized. The XPS spectra showed that the potentially multidentate ligands coordinated to the It atom through the nitrogen atoms, while the thiophene pendants did not participate in coordination to the It atom. (C) 2009 Elsevier B.V. All rights reserved.

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页码：149 / 153

页数：5

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