Berberine, an Epiphany Against Cancer

被引：227
作者：
Ortiz, Luis Miguel Guaman [1 ,2 ]
Lombardi, Paolo [3 ]
Tillhon, Micol [1 ]
Scovassi, Anna Ivana [1 ]
机构：
[1] Ist Genet Mol CNR, I-27100 Pavia, Italy
[2] Univ Tecn Particular Loja, Dept Ciencias Salud, Calle Paris 1101608, Loja, Ecuador
[3] Naxospharma, I-20026 Novate Milanese, Italy
来源：
MOLECULES | 2014年 / 19卷 / 08期
关键词：
apoptosis; autophagy; berberine; cancer; traditional medicine; ACTIVATED PROTEIN-KINASE; DNA TOPOISOMERASE-I; INDUCED GROWTH-INHIBITION; LEUKEMIA HL-60 CELLS; INDUCED APOPTOSIS; DOWN-REGULATION; ALKALOID BERBERINE; CARCINOMA-CELLS; COLON-CANCER; LUNG-CANCER;
D O I：
10.3390/molecules190812349
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alkaloids are used in traditional medicine for the treatment of many diseases. These compounds are synthesized in plants as secondary metabolites and have multiple effects on cellular metabolism. Among plant derivatives with biological properties, the isoquinoline quaternary alkaloid berberine possesses a broad range of therapeutic uses against several diseases. In recent years, berberine has been reported to inhibit cell proliferation and to be cytotoxic towards cancer cells. Based on this evidence, many derivatives have been synthesized to improve berberine efficiency and selectivity; the results so far obtained on human cancer cell lines support the idea that they could be promising agents for cancer treatment. The main properties of berberine and derivatives will be illustrated.
引用
收藏
页码：12349 / 12367
页数：19
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