Molecular diagnostics of neurodegenerative disorders

被引:100
作者
Agrawal, Megha [1 ]
Biswas, Abhijit [2 ]
机构
[1] Univ Arkansas, Dept Biol, 2801 South Univ Ave, Little Rock, AR 72204 USA
[2] Univ Notre Dame, Dept Elect Engn, Ctr Nano Sci & Technol, Notre Dame, IN 46556 USA
关键词
biomarkers; miRNAs; Alzheimer' s disease; Parkinson' Amyotrophic lateral sclerosis; Huntington' neurodegeneration; neurons;
D O I
10.3389/fmolb.2015.00054
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Molecular diagnostics provide a powerful method to detect and diagnose various neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of such diagnosis allows early detection and subsequent medical counseling that help specific patients to undergo clinically important drug trials. This provides a medical pathway to have better insight of neurogenesis and eventual cure of the neurodegenerative diseases. In this short review, we present recent advances in molecular diagnostics especially biomarkers and imaging spectroscopy for neurological diseases. We describe advances made in Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), and finally present a perspective on the future directions to provide a framework for further developments and refinements of molecular diagnostics to combat neurodegenerative disorders.
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页数:10
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