An update on colorectal cancer microenvironment, epigenetic and immunotherapy

被引：63
作者：
Jin, Ketao [1 ]
Ren, Chengcheng [2 ]
Liu, Yuyao [3 ]
Lan, Huanrong [4 ]
Wang, Zhen [2 ]
机构：
[1] Zhejiang Univ, Sch Med, Jinhua Hosp, Dept Colorectal Surg, Jinhua 321000, Zhejiang, Peoples R China
[2] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Rehabil & Sports Med Res Inst Zhejiang Prov, Peoples Hosp, Hangzhou 310014, Peoples R China
[3] Zhejiang Univ, Sch Med, Shaoxing Hosp, Dept Colorectal Surg, Shaoxing 312000, Zhejiang, Peoples R China
[4] Zhejiang Univ, Sch Med, Shaoxing Hosp, Dept Breast & Thyroid Surg, Shaoxing 312000, Zhejiang, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 89卷
基金：
中国国家自然科学基金;
关键词：
Colorectal cancer; Immunotherapy; Cancer microenvironment; Immune checkpoint inhibitor; Epigenetic; ENDOTHELIAL GROWTH-FACTOR; TUMOR-ASSOCIATED MACROPHAGES; INFILTRATING DENDRITIC CELLS; IMMUNE CHECKPOINT BLOCKADE; T REGULATORY CELLS; SUPPRESSOR-CELLS; PROGNOSTIC VALUE; ANTIGEN PRESENTATION; POOR-PROGNOSIS; UP-REGULATION;
D O I：
10.1016/j.intimp.2020.107041
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
y Colorectal cancer (CRC) is considered as the second most common cancer worldwide. For the past few years, the role of immunotherapy has been extensively studied and it has been demonstrated that its related approaches, such as programmed death-1 (PD-1) inhibitors, are promising. In addition to identifying molecular characteristics of tumor cells, recent studies are mainly focused on the profiling of tumor microenvironment. Dissecting immune status of a tumor is interesting, since development of a tumor is associated with deficiencies relate to immune defense, immune surveillance and immune hemostasis. In this review, we discuss main obstacles of immunotherapy including immunosuppressive niche and low immunogenicity of CRC as well as reviewing current achievements in immunotherapy.
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页数：8
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