Formation of Ordered Cellular Structures in Suspension via Label-Free Negative Magnetophoresis

被引：86

作者：

Krebs, Melissa D. ^{[1
]}

Erb, Randall M. ^{[2
]}

Yellen, Benjamin B. ^{[2
]}

Samanta, Bappaditya ^{[3
]}

Bajaj, Avinash ^{[3
]}

Rotello, Vincent M. ^{[3
]}

Alsberg, Eben ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Duke Univ, Ctr Biol Inspired Mat & Mat Syst, Durham, NC 27708 USA

[3] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 05期

基金：

美国国家科学基金会;

关键词：

MAGNETITE NANOPARTICLES; AGGREGATION; DIFFERENTIATION; ANGIOGENESIS; GROWTH;

D O I：

10.1021/nl803757u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The creation of ordered cellular structures is important for tissue engineering research. Here, we present a novel strategy for the assembly of cells into linear arrangements by negative magnetophoresis using inert, cytocompatible magnetic nanoparticles. In this approach, magnetic nanoparticles dictate the cellular assembly without relying on cell binding or uptake. The linear cell structures are stable and can be further cultured without the magnetic field or nanoparticles, making this an attractive tool for tissue engineering.

引用

页码：1812 / 1817

页数：6

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