A neurocentric perspective on glioma invasion

被引：647

作者：

Cuddapah, Vishnu Anand ^{[1
]}

Robel, Stefanie ^{[1
]}

Watkins, Stacey ^{[1
]}

Sontheimer, Harald ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Ctr Glial Biol Med, Dept Neurobiol, Birmingham, AL 35294 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2014年 / 15卷 / 07期

基金：

美国国家卫生研究院;

关键词：

BLOOD-BRAIN-BARRIER; CELL-MIGRATION; EXTRACELLULAR-MATRIX; MALIGNANT GLIOMA; IN-VIVO; OLIGODENDROCYTE PROGENITORS; POTASSIUM CHANNELS; HUMAN GLIOBLASTOMA; LAMININ ISOFORMS; CYSTINE UPTAKE;

D O I：

10.1038/nrn3765

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to escape complete surgical resection and chemo- and radiation therapy. Gliomas use the same tortuous extracellular routes of migration that are travelled by immature neurons and stem cells, frequently using blood vessels as guides. They repurpose ion channels to dynamically adjust their cell volume to accommodate to narrow spaces and breach the blood brain barrier through disruption of astrocytic endfeet, which envelop blood vessels. The unique biology of glioma invasion provides hitherto unexplored brain-specific therapeutic targets for this devastating disease.

引用

页码：455 / 465

页数：11

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